Synthesis of Iron Ferrite Fe3O4 Nanoparticles and Investigation of Physical Properties and their Magnetism for Use in Drug Delivery
Keywords:
Magnetic Beads, Magnetite, Alginate, Chitosan, SonochemistryAbstract
The technology of combining magnetic oxide nanoparticles with polymers plays an important role in physics and material science. They are used in medicine as a targeted drug delivery system. Magnetite (Fe3O4) is one of the most important It is the most widely used iron oxide and has various applications in nanotechnology. In this research, first, iron oxide nanoparticles were made by the sonochemical method. To characterize the prepared samples, we used the diffraction scheme, the infrared Fourier transform spectrum, and a magnetometer with an oscillating sample. In the diffraction scheme, magnetite is the phase. It is original, and the resulting powder is crystalline and has an FCC cubic spinel structure. Using Scherer's formula, the approximate average size of nanocrystals for the Miller index (133) was found to be about 37 nm. In this research, alginate magnetic beads with chitosan coatings were prepared. According to the DLS results, the average diameter size of the nanoparticle with two different methods is about 3 mm and 13 nm. is confirmed in this nanocomposite. For (Fe3O4) magnetic beads, absorption bands were observed at 73.3061, 13.3130, 61.61, and 3611 cm1. Residual rings (H-M) of magnetite nanoparticles magnetic beads were measured at room temperature by a magnetometer with an oscillating sample, and the results of the measurements show a behavior similar to paramagnetic clouds in the produced nanostructures. The saturation magnetization values of magnetite nanoparticles were obtained (131.03 and 1117.30 g/emu, respectively). Considering that the magnetic beads are made of 13 nm, they have more drug-loading capability. Due to the similar behaviors of the paramagnetic cloud phase, the produced magnetic beads are most likely to have favorable performance in the targeted drug delivery system and heat therapy.
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